Population Genetics and Evolution Theory

Population structure, Random mating population, Concepts of a population (gene pool, derne and panmictic unit) Genetic and phenotypic variation in a population, allele frequencies and genotype frequencies at a locus 3 Hardy-Weinberg Law- Assumptions and implications, Hardy-Weinberg equilibrium for single gene loci establishment of Extensions of Hardy-Weinberg Law-multiple alleles, X-linked gene 5/ Linkage disequilibrium Snyder's ratios SYSTEMATIC & DISPERSIVE FORCES UNIT - II: 1. Selection fitness, patterns of natural selection, general selection equation, equilibrium under selection, Selection favouring heterozygote (stable equilibrium, balanced polymorphism, sicke cell anemia, heterozygote advantage) - selection against heterozygote (unstable equilibrium, Rh incompatibility), complete elimination of recessive gene 2 Mutation - mutation models, influence of mutation.on allele frequency and autazygosity, balance between forward and backward mutation, Interaction of mutation with selection Genetic load - mutational and segregational , Gene flow - Migration - Population structure and gene flow - Wahlund effect